女王调教

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  张诗宜

  张诗宜，男，1986年出生，博士，国家级青年人才项目获得者，女王调教 长聘副教授，博士生导师。2008年本科毕业于北京大学的化学与分子工程女王调教 。2013年毕业于美国圣路易斯华盛顿大学，师从Karen Wooley院士，主要研究方向为可降解高分子材料的生物应用。2013-2016年，在美国麻省理工女王调教 三院院士（科女王调教 ，工程院，医女王调教 ）Robert Langer教授课题组从事博士后研究，主要研究方向为胃肠道药物缓控释。在Nature Materials, Science Translational Medicine, Science Advances, Nature Communications, eLife, Journal of the American Chemical Society, ACS Nano, Advanced Materials, Advanced Functional Materials, Macromolecules and ACS Macro Letters等顶级学术期刊发表论文40余篇。申请专利20多项，技术成功转让10多项。他帮助成立生物技术公司Lyndra，将新型的长效口服新剂型推进到了临床三期。他主导成立了生物技术公司OnQuality（岸阔医药），将多个治疗副作用的药物推进到了临床阶段。目前的研究方向主要围绕着抗癌药物的副作用，口服不吸收药物展开。研究思路是做原创的，有趣的，有临床意义的研究。

北京大学，本科，2004-2008

华盛顿大学圣路易斯，博士，2008-2013

麻省理工女王调教 ，博士后，2013-2016

Tian, M.; Mu, X.; Fan, D.; Liu, Z.; Liu, Q.; Yue, K.; Song, Z.; Luo, J.; Zhang, S.* "A Transformable Mucoadhesive Microgel Network for Noninvasive Multimodal Imaging and Radioprotection of a Large Area of the Gastrointestinal Tract" Adv. Mater. , 2023 Accepted 

Xiang, J.; Wang, H.; Tao, Q.; Li, W.; Huang, Y.; Zhang, Y.; Yang, L.; Zhang, S.* " CDK4/6 inhibitor modulating active and quiescent intestinal stem cells for prevention of chemotherapy-induced diarrhea" J. Pathol. , 2023 Accepted 

Yang, B.; Xie, X.; Wu, Z.; Lv, D.;Hu, J.; Chen, Y.; Li, J.; Li, J.; Luo, S.; Luo, J.; Zhang, S.* "DNA damage-mediated cellular senescence promotes hand–foot syndrome that can be relieved by thymidine prodrug" Genes Dis. , 2022 Accepted 

Yang, B.; Xie, X.; Lv, D.; Hu, J.; Chen, Y.; Wu, Z.; Luo, S.; Zhang, S.* "Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil" Br. J. Cancer, 2022 128(2), 219-231.

Yang, J.; Wang, X.; Wang, B.*; Park, K.*; Wooley K. L.*; Zhang, S.* "Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers" Adv. Drug Deliv. Rev., 2022 109, 114525

Tian, M.; Fan, D.; Liu, Z.; Mu, X.; Tao, Q.; Yu, C.; Zhang, S.* "Oral Supramolecular Adsorbent for Preventing Chemo-Induced Gastrointestinal Mucositis & Microbial Dysbiosis and for Enhancing Chemoimmunotherapy" Adv. Mater., 2022 Dec;34(50):e2205299.

Chen, L.; You, Q.; Liu, M.; Li, S.; Wu, Z.; Hu, J.; Ma, Y.; Xia, L.; Zhou, Y.; Xu, N.*; Zhang, S.* "Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy" eLife, 2022 (11): e72443

Xie, X.; Chen, L.; Liu X.; Wu, Z.; Lv, D.; Ma, Y.; Luo, J.; Zhang, S.* "Prophylactic effect of nitric oxide donors on rat models of EGFR inhibitors induced-cutaneous toxicities" J. Invest. Dermatol., 2022. May 23; S0022-202X(22)00399-2.

Chen, L.; Wu, Z.; Yang, L.; Chen, Y.; Wang, W.; Cheng, L.; Li, C.; Lv, D.; Xia, L.; Chen, J.; Tang, L.*; Zhang, L.*; Zhang, S.*; Luo, J.* "Nitric Oxide in Multikinase Inhibitor-induced Hand-Foot Skin Reaction" Transl. Res., 2022, 245: 82-98

Chen, L.; You, Q.; Lv, D.; Li, S.; Zhang, S.* "GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib" Acta. Pharmacol. Sin., 2021, 43: 1534–1543

Tian, M.; Xing, R.; Guan, J.; Yang, B.; Zhao, X.; Yang, J.; Zhan, C.*; Zhang, S.* "A Nanoantidote Alleviates Glioblastoma Chemotoxicity without Efficacy Compromise" Nano Lett. 2021, 21, 12, 5158-5166

Zhao, X.; Zhang, H.; Li, J.; Tian, M.; Yang, J.; Sun, S.; Hu, Q.; Yang, L.; Zhang, S.*;"Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders" Sci. Adv., 2021, 7, 14, eabf7311

Bellinger, A. M.*; Jafari, M.*; Grant, T. M.*; Zhang, S. *; Slater, H.; Wenger, E.; Mo, S.; Lee, Y-A. L.; Mazdiyasni, H.; Kogan, L.; Barman, R.; Cleveland, C.; Booth, L.; Bensel, T.; Minahan, D.; Hurowitz, H. M.; Tai, T.; Daily, J.; Nikolic, B.; Wood, L.; Eckhoff, P.; Langer, R.; Traverso, G. "Oral, Ultra–long-lasting Drug Delivery: Application Toward Malaria Elimination Goals" Sci. Transl. Med. , 2016 16;8(365):365ra157 (* equal contribution)

Zhang, S.; Bellinger, A. M.; Glettig, D. L.; Barman, R.; Lee, Y.-A. L.; Zhu, J.; Cleveland, C.; Montgomery, V. A.; Gu, L.; Nash, L. D.; Maitland, D. J.; Langer, R.; Traverso G. "A pH-responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices" Nat. Mater., 2015, 14, 1065-1071

科技英语写作与交流 (GE7001) 春季

转化医学与职业发展 (BME4203) 秋季